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thomas chang ubc

View Thomas Chang's business profile as Associate Dean, Graduate and Postdoctoral Studies at The University of British Columbia. In the present study, constitutive expression of various xenobiotic-metabolizing enzymes (Study 1) and their regulation by 17β-estradiol benzoate (EB) (Study 2) and an endocrine disrupting chemical, bisphenol A (BPA) (Study 3), were investigated in adult rat testis. Nuclear receptors such as constitutive androstane receptor and pregnane X receptor are potential therapeutic targets for various human diseases. Lastly, the contributions of hepatic CYP-enzymes in the oxidative metabolism of VPA were characterized in human liver microsomes. There are many splice variants of the human constitutive androstane receptor, several of which are expressed predominantly in the liver. Stephanie E. Chang is a UBC professor with a joint appointment in the School of Community and Regional Planning and the Institute for Resources, Environment, and Sustainability. "Killam Faculty Research Fellowship". Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting. Address the faculty members by name. In Study 2, subcutaneous (sc) treatment of EB at 0.004, 0.04, 0.4 or 4 μmol/kg once daily for 14 days suppressed testicular expression of CYP1B1, CYP2A1 and CYP17A1 at each of the dosages tested. Current Student - Faculty of Arts She held a Canada Research Chair (Tier 2) in Disaster Management and Urban Sustainability from 2004 to 2013. Highlight your achievements and why you are a top student. Thomas Hu. However, the results from (E)-2-ene-VPA experiments indicated the toxic potential of in situ generated (E)-2,4-diene-VPA in sandwich-cultured rat hepatocytes, when generated at high concentrations. This will pave the way for future drug development efforts to find selective, potent and effective modulators. Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles. 2002. Chang TKH. Furthermore, VPA-associated GSH depletion appeared not to be a factor in the mitochondrial dysfunction, but may play a partial role in VPA-induced cytotoxicity. Burroughs Wellcome Fund (U.S.A.). Currently, Dr. Chang is Professor and Associate Dean, Graduate and Postdoctoral Studies and a UBC Distinguished University Scholar. Identify specific faculty members who are conducting research in your specific area of interest. Establish that your research interests align with the faculty member’s research interests. Join Facebook to connect with Thomas Chang and others you may know. Shawn Chang, 3rd year Science student (Combined Honours in Biochemistry and Forensic Science) You can learn what you really love “I think the biggest difference between uni and high school is that in university, you have the autonomy to choose topics that you actually want to learn about. EB and BPA did not produce a general down-regulation of testicular protein expression because neither of these chemicals decreased calnexin protein (endoplasmic reticulum marker) levels. Dr. Thomas K. H. Chang completed a bachelor of science and a doctor of philosophy in pharmaceutical sciences at UBC. Based on the modulatory experiments with phenobarbital and 1-aminobenzotriazole, in situ generated (E)-2,4-diene-VPA did not appear to contribute to VPA toxicity in sandwich-cultured rat hepatocytes. (E)-2-ene-VPA, which is a β-oxidation metabolite of VPA, was also included in the experiments concerning (E)-2,4-diene-VPA, as it formed relatively large amounts of (E)-2,4-diene-VPA. People & Change: Thomas Veal October 24, 2019. For halofantrine no significant increase was seen in the bioavailability for the super-SNEDDS however, for fenofibrate the AUC of the super-SNEDDS was significantly larger than for the SNEDDS.The dynamic in vitro lipolysis model is typically used in the evaluation of digestibility and solubilization capacity of SNEDDS and other LbDDS. Clinical use of VPA is associated with a rare, but possibly fatal, idiosyncratic hepatotoxicity. Office Phone Number: 604-225-5836. I finished my Ph.D. in statistics at the University of British Columbia. Professor and Associate Dean, Graduate and Postdoctoral Studies, Office of the Associate Dean, Graduate and Postdoctoral Studies, Bachelor of Pharmaceutical Sciences Degree, Continuing Pharmacy Professional Development, Data Analytics, Statistics and Informatics, Nuclear Receptor Regulation of Hepatic Cytochrome P450 Enzymes, The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins, Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation, Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine, Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor. NNRTI therapy is associated with pharmacokinetic drug interactions, the underlying mechanisms of which are poorly understood. The overall experimental strategy was to modulate the in situ formation of these two metabolites and determine the consequences on VPA toxicity in sandwich-cultured rat hepatocytes. Future studies should investigate the role of VPA-CoA thioester formation on VPA toxicity in sandwich-cultured rat hepatocytes.View record, Valproic acid (VPA) therapy is associated with a rare but severe hepatotoxicity. Overall, the results of the present study add value to the existing knowledge on the role of reactive metabolites of VPA in VPA hepatotoxicity. Alternatively, you may have mistakenly bookmarked the web login form instead of the actual web site you wanted to bookmark or used a link created by somebody else who made the same mistake. Studies are underway that focus on natural products and synthetic drugs. In order to examine precipitation of poorly water soluble drugs dosed in LbDDS invivo the gastric and intestinal content of rats was examined for precipitated crystalline drug using XRPD and PLM. In summary, CYP1B1, CYP2A1, CYP17A1, mEH and POR were detected in rat testis and their expression was confined to interstitial cells (CYP1B1, CYP2A1, CYP17A1, mEH and POR) and seminiferous tubules (mEH and POR). Our findings in SCRH indicated that (E)-2,4-diene-VPA was the only exogenously administered metabolite tested that was consistently more toxic than VPA. 74, pp. transporters such as P-glycoprotein and drug-metabolizing enzymes such as cytochromes P450), and regulate the transport, bioactivation and detoxification of xenobiotics (e.g. Izaak Walton Killam Trust. The effects of glutathione supplementation on the attenuation of the markers for VPA-induced toxicities were investigated. These nuclear receptors include constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Chang TKH. MicroRNAs are small non-coding RNAs that are post-transcriptional regulators causing mRNA degradation or translational repression by binding to complementary regions in target mRNA. Bioinformatic analysis (www.microRNA.org) predicted sequence complementarity between hsa-miR-18a-5p and PXR. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are important anti-retroviral drugs indicated in combination therapy of human immunodeficiency virus-1 (HIV-1) infection. Ensure to craft compelling answers to these questions. (604) 822-7795 Chang TKH. Thomas Chang & Co is a law firm located in Chinatown, Sydney with attorneys, conveyancers and Chinese solicitors acting as migration agent dealing with … Current postdoctoral researchers Chang Lu (Aug 2018 – May 2021) Ph.D. in Strategic Management and Organization at the Alberta School of Business, University of Alberta Theoretically, he focuses on the processes by which actors instigate change in highly institutionalized contexts. Lipid-based drug delivery systems (LbDDS) are a versatile group of formulations including self-nanoemulsifying drug delivery systems (SNEDDS). GSH may serve a protective role against VPA-induced oxidative stress in SCRH. I want to thank the leaders and faculties at UBC and our many ongoing presenting partners. In contrast, over-expression of hsa-miR-18a-5p decreased PXR mRNA expression and CYP3A4 inducibility by rilpivirine and rifampin. At UBC Chemistry: Thomas Veal October 24, 2019 your achievements and why you are in/already! Can be transformed to be thomas chang ubc better and wilder to submitting an.. Emails to everyone in the department hoping for a match interest to dr. Chang is Professor and Dean... Also completed the faculty certificate program on Teaching and learning in Higher Education at UBC and many! 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